Grady W. Miller

Primary Appointment

Associate Professor, Radiology and Medical Imaging

Education

  • BS, University of Maryland
  • PhD, Princeton University

Selected Publications

2023

Garrison, W. J., Mugler, J. P. I. I. I., Mata, J. F., Nunoo-Asare, R. N., Shim, Y. M., & Miller, G. W. (2023). Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (201). doi:10.3791/65982

Garrison, W. J., Qing, K., He, M., Zhao, L., Tustison, N. J., Patrie, J. T., . . . Miller, G. W. (2023). Lung Volume Dependence and Repeatability of Hyperpolarized 129Xe MRI Gas Uptake Metrics in Healthy Volunteers and Participants with COPD. RADIOLOGY-CARDIOTHORACIC IMAGING, 5(3). doi:10.1148/ryct.220096

Fisher, D. G., Sharifi, K. A., Ulutas, E. Z., Kumar, J. S., Kalani, M. Y. S., Miller, G. W., . . . Tvrdik, P. (2023). Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 43(6), 958-970. doi:10.1161/ATVBAHA.122.318938

Garrison, W. J. J., Qing, K., Tafti, S., Mugler, J. P. P., Shim, Y. M., Mata, J. F. F., . . . Miller, G. W. (2023). Highly accelerated dynamic acquisition of 3D grid-tagged hyperpolarized-gas lung images using compressed sensing. MAGNETIC RESONANCE IN MEDICINE, 89(6), 2255-2263. doi:10.1002/mrm.29595

2022

Leung, S. A., Moore, D., Gilbo, Y., Snell, J., Webb, T. D., Meyer, C. H., . . . Pauly, K. B. (2022). Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-17319-4

2021

Sheybani, N. D., Witter, A. R., Garrison, W. J., Miller, G. W., Price, R. J., & Bullock, T. N. J. (2022). Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound. JOURNAL OF NEURO-ONCOLOGY, 156(1), 109-122. doi:10.1007/s11060-021-03887-4

Huang, B., Xiao, H., Liu, W., Zhang, Y., Wu, H., Wang, W., . . . Cai, J. (2021). MRI super-resolution via realistic downsampling with adversarial learning. PHYSICS IN MEDICINE AND BIOLOGY, 66(20). doi:10.1088/1361-6560/ac232e

Niedbalski, P. J., Hall, C. S., Castro, M., Eddy, R. L., Rayment, J. H., Svenningsen, S., . . . Woods, J. C. (2021). Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium. MAGNETIC RESONANCE IN MEDICINE, 86(6), 2966-2986. doi:10.1002/mrm.28985

Tustison, N. J., Altes, T. A., Qing, K., He, M., Miller, G. W., Avants, B. B., . . . Mata, J. F. (2021). Image- versus histogram-based considerations in semantic segmentation of pulmonary hyperpolarized gas images. MAGNETIC RESONANCE IN MEDICINE, 86(5), 2822-2836. doi:10.1002/mrm.28908

Sheybani, N. D., Breza, V. R., Paul, S., McCauley, K. S., Berr, S. S., Miller, G. W., . . . Price, R. J. (2021). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. JOURNAL OF CONTROLLED RELEASE, 331, 19-29. doi:10.1016/j.jconrel.2021.01.023

He, M., Qing, K., Tustison, N. J., Beaulac, Z., King, T. W., Huff, T. B., . . . Shim, Y. M. (2021). Characterizing Gas Exchange Physiology in Healthy Young Electronic-Cigarette Users with Hyperpolarized 129Xe MRI: A Pilot Study. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 16, 3183-3187. doi:10.2147/COPD.S324388

2020

Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2021). Transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption depends strongly on anesthesia. BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(2). doi:10.1002/btm2.10198

Myc, L., Qing, K., He, M., Tustison, N., Lin, Z., Manichaikul, A. W., . . . Shim, Y. M. (2021). Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI. THORAX, 76(2), 178-181. doi:10.1136/thoraxjnl-2020-214924

Tafti, S., Garrison, W. J., Mugler, J. P., Shim, Y. M., Altes, T. A., Mata, J. F., . . . Miller, G. W. (2020). Emphysema Index Based on Hyperpolarized 3He or 129Xe Diffusion MRI: Performance and Comparison with Quantitative CT and Pulmonary Function Tests. RADIOLOGY, 297(1), 201-210. doi:10.1148/radiol.2020192804

Curley, C. T., Mead, B. P., Negron, K., Kim, N., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. SCIENCE ADVANCES, 6(18). doi:10.1126/sciadv.aay1344

Gorick, C. M., Mathew, A. S., Garrison, W. J., Thim, E. A., Fisher, D. G., Copeland, C. A., . . . Price, R. J. (2020). Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(11), 5644-5654. doi:10.1073/pnas.1914595117

Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2020). Transcriptomic Response of Brain Tissue to Focused Ultrasound-Mediated Blood-Brain Barrier Disruption Depends Strongly on Anesthesia. doi:10.1101/2020.07.24.211136

Sheybani, N., Paul, S., McCauley, K., Breza, V., Berr, S., Miller, W., . . . Price, R. (2020). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. doi:10.1101/2020.07.27.223206

Curley, C. T., Stevens, A. D., Mathew, A. S., Stasiak, K., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound. THERANOSTICS, 10(19), 8821-8833. doi:10.7150/thno.47983

2019

Mead, B. P., Curley, C. T., Kim, N., Negron, K., Garrison, W. J., Song, J., . . . Price, R. J. (2019). Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System. SMALL, 15(49). doi:10.1002/smll.201903460

Hu, L., Huang, Q., Cui, T., Duarte, I., Miller, G. W., Mugler, J. P. I. I. I., . . . Cai, J. (2019). A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study. PHYSICS IN MEDICINE AND BIOLOGY, 64(10). doi:10.1088/1361-6560/ab160c

2018

Cui, T., Miller, G. W., Mugler, J. P. I. I. I., Cates, G. D. J., Mata, J. F., de Lange, E. E., . . . Cai, J. (2018). An initial investigation of hyperpolarized gas tagging magnetic resonance imaging in evaluating deformable image registration-based lung ventilation. MEDICAL PHYSICS, 45(12), 5535-5542. doi:10.1002/mp.13223

2017

Fielden, S. W., Feng, X., Zhao, L., Miller, G. W., Geeslin, M., Dallapiazza, R. F., . . . Meyer, C. H. (2018). A spiral-based volumetric acquisition for MR temperature imaging. MAGNETIC RESONANCE IN MEDICINE, 79(6), 3122-3127. doi:10.1002/mrm.26981

Zheng, Y., Marx, M., Miller, G. W., & Pauly, K. B. (2018). High sensitivity MR acoustic radiation force imaging using transition band balanced steady-state free precession. MAGNETIC RESONANCE IN MEDICINE, 79(3), 1532-1537. doi:10.1002/mrm.26793

Mead, B. P., Kim, N., Miller, G. W., Hodges, D., Mastorakos, P., Klibanov, A. L., . . . Price, R. J. (2017). Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model. NANO LETTERS, 17(6), 3533-3542. doi:10.1021/acs.nanolett.7b00616

Dallapiazza, R. F., Timbie, K. F., Holmberg, S., Gatesman, J., Lopes, M. B., Price, R. J., . . . Elias, W. J. (2018). Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound. JOURNAL OF NEUROSURGERY, 128(3), 875-884. doi:10.3171/2016.11.JNS16976

Choi, W. -G., Miller, G., Wallace, I., Harper, J., Mittler, R., & Gilroy, S. (2017). Orchestrating rapid long-distance signaling in plants with Ca2+, ROS and electrical signals. PLANT JOURNAL, 90(4), 698-707. doi:10.1111/tpj.13492

Timbie, K. F., Afzal, U., Date, A., Zhang, C., Song, J., Miller, G. W., . . . Price, R. J. (2017). MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 263, 120-131. doi:10.1016/j.jconrel.2017.03.017

Nacey, N. C., Geeslin, M. G., Miller, G. W., & Pierce, J. L. (2017). Magnetic Resonance Imaging of the Knee: An Overview and Update of Conventional and State of the Art Imaging. JOURNAL OF MAGNETIC RESONANCE IMAGING, 45(5), 1257-1275. doi:10.1002/jmri.25620

Shaver, A., Moon, J. D., Savacool, D., Zhang, W., Narang, G., Miller, G., . . . McGrath, J. E. (2017). Poly(2,6-dimethyl-1,4-phenylene oxide) blends with a poly(arylene ether ketone) for gas separation membranes. POLYMER, 114, 135-143. doi:10.1016/j.polymer.2017.02.041

2016

Handsfield, G. G., Inouye, J. M., Slane, L. C., Thelen, D. G., Miller, G. W., & Blemker, S. S. (2017). A 3D model of the Achilles tendon to determine the mechanisms underlying nonuniform tendon displacements. JOURNAL OF BIOMECHANICS, 51, 17-25. doi:10.1016/j.jbiomech.2016.11.062

Komlosi, P., Altes, T. A., Qing, K., Mooney, K. E., Miller, G. W., Mata, J. F., . . . Mugler, J. P. I. I. I. (2017). Signal-to-noise ratio, T2, and T2* for hyperpolarized helium-3 MRI of the human lung at three magnetic field strengths. MAGNETIC RESONANCE IN MEDICINE, 78(4), 1458-1463. doi:10.1002/mrm.26516

Zheng, Y., Miller, G. W., Tobias, W. A., & Cates, G. D. (2016). A method for imaging and spectroscopy using γ-rays and magnetic resonance. NATURE, 537(7622), 652-+. doi:10.1038/nature19775

Flors, L., Mugler, J. P. I. I. I., de Lange, E. E., Miller, G. W., Mata, J. F., Tustison, N., . . . Altes, T. A. (2016). Hyperpolarized Gas Magnetic Resonance Lung Imaging in Children and Young Adults. JOURNAL OF THORACIC IMAGING, 31(5), 285-295. doi:10.1097/RTI.0000000000000218

Menon, R., Miller, G. W., Jeudy, J., Rajagopalan, S., & Shin, T. (2017). Free Breathing Three-Dimensional Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Using Outer Volume Suppressed Projection Navigators. MAGNETIC RESONANCE IN MEDICINE, 77(4), 1533-1543. doi:10.1002/mrm.26234

Johnson, C., Miller, G. R., Baker, B. A., Hollander, M., Kashon, M. L., Waugh, S., & Krajnak, K. (2016). Changes in the expression of calcitonin gene-related peptide after exposure to injurious stretch-shortening contractions. EXPERIMENTAL GERONTOLOGY, 79, 1-7. doi:10.1016/j.exger.2016.03.006

2015

Flors, L., Altes, T. A., Mugler, J. P., de Lange, E. E., Miller, G. W., Mata, J. F., . . . Hersman, F. W. (2015). New insights into lung diseases using hyperpolarized gas MRI. Radiología (English Edition), 57(4), 303-313. doi:10.1016/j.rxeng.2014.12.003

Komlosi, P., Altes, T. A., Qing, K., Mooney, K. E., Miller, G. W., Mata, J. F., . . . Mugler, J. P. I. I. I. (2015). Regional Anisotropy of Airspace Orientation in the Lung as Assessed With Hyperpolarized Helium-3 Diffusion MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 42(6), 1777-1782. doi:10.1002/jmri.24950

Miller, G. W., Eames, M., Snell, J., & Aubry, J. -F. (2015). Ultrashort echo-time MRI versus CT for skull aberration correction in MR-guided transcranial focused ultrasound: In vitro comparison on human calvaria. MEDICAL PHYSICS, 42(5), 2223-2233. doi:10.1118/1.4916656

Moyer, L. C., Timbie, K. F., Sheeran, P. S., Price, R. J., Miller, G. W., & Dayton, P. A. (2015). High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. JOURNAL OF THERAPEUTIC ULTRASOUND, 3. doi:10.1186/s40349-015-0029-4

Flors, L., Altes, T. A., Mugler, J. P. I. I. I., de Lange, E. E., Miller, G. W., Mata, J. F., . . . Hersman, F. W. (2015). New insights into lung diseases using hyperpolarized gas MRI. RADIOLOGIA, 57(4), 303-313. doi:10.1016/j.rx.2014.12.011

2014

Zhang, Y., Aubry, J. -F., Zhang, J., Wang, Y., Roy, J., Mata, J. F., . . . Wintermark, M. (2015). DEFINING THE OPTIMAL AGE FOR FOCAL LESIONING IN A RAT MODEL OF TRANSCRANIAL HIFU. ULTRASOUND IN MEDICINE AND BIOLOGY, 41(2), 449-455. doi:10.1016/j.ultrasmedbio.2014.09.029

Qing, K., Altes, T. A., Tustison, N. J., Feng, X., Chen, X., Mata, J. F., . . . Mugler, J. P. I. I. I. (2015). Rapid Acquisition of Helium-3 and Proton Three-Dimensional Image Sets of the Human Lung in a Single Breath-Hold Using Compressed Sensing. MAGNETIC RESONANCE IN MEDICINE, 74(4), 1110-1115. doi:10.1002/mrm.25499

Zheng, Y., Cates, G. D., Tobias, W. A., Mugler, J. P. I. I. I., & Miller, G. W. (2014). Very-low-field MRI of laser polarized xenon-129. JOURNAL OF MAGNETIC RESONANCE, 249, 108-117. doi:10.1016/j.jmr.2014.09.024

Qing, K., Mugler, J. P. I. I. I., Altes, T. A., Jiang, Y., Mata, J. F., Miller, G. W., . . . Ruppert, K. (2014). Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI. NMR IN BIOMEDICINE, 27(12), 1490-1501. doi:10.1002/nbm.3179

Miller, G. W., Mugler, J. P. I. I. I., Sa, R. C., Altes, T. A., Prisk, G. K., & Hopkins, S. R. (2014). Advances in functional and structural imaging of the human lung using proton MRI. NMR IN BIOMEDICINE, 27(12), 1542-1556. doi:10.1002/nbm.3156

Nance, E., Timbie, K., Miller, G. W., Song, J., Louttit, C., Klibanov, A. L., . . . Price, R. J. (2014). Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood - brain barrier using MRI-guided focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 189, 123-132. doi:10.1016/j.jconrel.2014.06.031

Timbie, K., Nance, E., Zhang, C., Miller, W., Song, J., Hanes, J., & Price, R. (2014). Ultrasound-mediated nanoparticle delivery across the blood-brain barrier. FASEB JOURNAL, 28(1). Retrieved from https://www.webofscience.com/

2013

Phillips, L. C., Puett, C., Sheeran, P. S., Dayton, P. A., Miller, G. W., & Matsunaga, T. O. (2013). Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating (vol 134, pg 1473, 2013). JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 134(6), 4575. doi:10.1121/1.4828830

Scirica, B. M., Bhatt, D. L., Braunwald, E., Steg, P. G., Davidson, J., Hirshberg, B., . . . Simmons, D. (2013). Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus. NEW ENGLAND JOURNAL OF MEDICINE, 369(14), 1317-1326. doi:10.1056/NEJMoa1307684

Phillips, L. C., Puett, C., Sheeran, P. S., Dayton, P. A., Miller, G. W., & Matsunaga, T. O. (2013). Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 134(2), 1473-1482. doi:10.1121/1.4812866

Qing, K., Ruppert, K., Jiang, Y., Mata, J. F., Miller, W., Shim, Y. M., . . . Mugler, J. P. I. I. I. (2014). Regional Mapping of Gas Uptake by Blood and Tissue in the Human Lung Using Hyperpolarized Xenon-129 MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 39(2), 346-359. doi:10.1002/jmri.24181

2012

Fonvieille, H., Laveissiere, G., Degrande, N., Jaminion, S., Jutier, C., Todor, L., . . . Zhou, Z. -L. (2012). Virtual Compton scattering and the generalized polarizabilities of the proton at Q2=0.92 and 1.76 GeV2. PHYSICAL REVIEW C, 86(1). doi:10.1103/PhysRevC.86.015210

2011

Dregely, I., Ruset, I. C., Mata, J. F., Ketel, J., Ketel, S., Distelbrink, J., . . . Ruppert, K. (2012). Multiple-Exchange-Time Xenon Polarization Transfer Contrast (MXTC) MRI: Initial Results in Animals and Healthy Volunteers. MAGNETIC RESONANCE IN MEDICINE, 67(4), 943-953. doi:10.1002/mrm.23066

Hamedani, H., Kadlecek, S. J., Emami, K., Kuzma, N. N., Xu, Y., Xin, Y., . . . Rizi, R. R. (2012). A multislice single breath-hold scheme for imaging alveolar oxygen tension in humans. MAGNETIC RESONANCE IN MEDICINE, 67(5), 1332-1345. doi:10.1002/mrm.23125

Dregely, I., Mugler, J. P. I. I. I., Ruset, I. C., Altes, T. A., Mata, J. F., Miller, G. W., . . . Ruppert, K. (2011). Hyperpolarized Xenon-129 Gas-Exchange Imaging of Lung Microstructure: First Case Studies in Subjects With Obstructive Lung Disease. JOURNAL OF MAGNETIC RESONANCE IMAGING, 33(5), 1052-1062. doi:10.1002/jmri.22533

Altes, T., Johnson, M. A., Miller, G. W., Mugler, J. P., Flors, L., Mata, J., . . . Botfield, M. C. (2011). HYPERPOLARIZED HELIUM-3 MAGNETIC RESONANCE IMAGING OF CFTR POTENTIATOR THERAPY IN SUBJECTS WITH CYSTIC FIBROSIS AND THE G551D MUTATION. PEDIATRIC PULMONOLOGY, 284. Retrieved from https://www.webofscience.com/

2010

Mugler, J. P. I. I. I., Altes, T. A., Ruset, I. C., Dregely, I. M., Mata, J. F., Miller, G. W., . . . Ruppert, K. (2010). Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(50), 21707-21712. doi:10.1073/pnas.1011912107

Tustison, N. J., Awate, S. P., Cai, J., Altes, T. A., Miller, G. W., de lange, E. E., . . . Gee, J. C. (2010). Pulmonary Kinematics From Tagged Hyperpolarized Helium-3 MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 31(5), 1236-1241. doi:10.1002/jmri.22137